Nancy Eun-joo Lee
Department of Chemistry, Simmons College
300 The Fenway, Boston, MA 02115
(617) 521-2732; (617) 521-3199 (Fax)
Massachusetts Institute of Technology, Cambridge, Massachusetts, 1993-1994.
NIH Postdoctoral Fellow. Advisor: Professor Stephen L. Buchwald
Brown University, Providence, Rhode Island, 1989-1993.
Ph.D. in Organic Chemistry, July 1993.
Dissertation Title: "Diastereoselective Synthesis of Beta-Hydroxyacids Using Acyloxysilanes and Synthesis of a Vitamin D3 Metabolite and Analogues" Advisor: Professor Paul G. Williard
University of Pennsylvania, Philadelphia, Pennsylvania.
B.A. in Chemistry, May 1985.
Assistant Professor of Chemistry, Simmons College, Boston, MA, 1994- present
Teaching responsibilities include organic chemistry I and II, advanced organic chemistry, and independent research. Research interests are synthesis of biologically active compounds and development of new synthetic methodology to medium size lactams.
Postdoctoral Fellow, M.I.T., 1993-1994.
Research involved enantioselective reduction of enamines and kinetic resolution of imines using a chiral titanium catalyst.
Research Assistant, Brown University, 1990-1993.
Diastereoselective syntheses of b-hydroxyacids were studied using acyloxysilanes as precursors in aldol reactions. A vitamin D3 metabolite and analogues were synthesized using a novel route to the A ring. The metabolite and analogues were shown to be active in cell differentiation assays.
Teaching Assistant, Brown University, 1989-1990.
Supervised sophomore level organic chemistry laboratory sections. Prepared and presented review sessions.
Associate Chemist, Wyeth-Ayerst Research, 1986-1989.
Devised and executed multistep synthesis of various novel organic targets which were active in anti-ulcer, anxiolytic, and excitatory amino acid antagonist programs. The synthesis of seventy-five novel compounds resulted in three patents and two publications.
Staff Chemist, Merck Sharp & Dohme Labs., 1985-1986.
Quality control and on-line searching of in-house compound database.
"The Chemistry Outreach Program: Women Undergraduates presenting Chemistry to Middle School Students" Nancy Lee and Kathryn Schreiber J. Chem. Ed., 1999, 76 (7), 917.
" Mentoring Program with Hands-on Laboratory Experiments" Nancy Lee Journal of College Science Teaching, accepted for publication.
"Practical Approaches to Remote Asymmetric Induction in Steroidal Side-Chains Utilizing Oxazaborolidine Reagents" M. N. Rao, M. A. McGuigan, X. Zhang, W. A. Kinney, M. Bulliard, B. Laboue, N. E. Lee J. Org. Chem. 1997, 62, 4541.
"Synthesis, Stereochemistry, and Biological Activity of 1a,23,25-Trihydroxy-24-oxovitamin D3, a Major Natural Metabolite of 1a,25-Dihydroxyvitamin D3" N. E. Lee, G. S. Reddy, A. J. Brown, P. G. Williard Biochemistry 1997, 36, 9429.
"Kinetic Resolution of Racemic 2,5-Disubstituted-1-Pyrrolines via Asymmetric Reduction with a Chiral Titanocene Catalyst" Viso, A.; Lee, N. E.; Buchwald, S. L. J. Am. Chem. Soc. 1994, 116, 9373
"Asymmetric Hydrogenation of Enamines with a Chiral Titanocene Catalyst" Lee, N. E.; Buchwald, S. L. J. Am. Chem. Soc. 1994, 116, 5985.
"Bioisosteric Replacement of the a-Amino Carboxylic Acid Functionality in 2-Amino-5-Phosphonovaleric acid (AP5) Yields Unique 3,4-Diamino-3-Cyclobutene-1,2-Dione Containing NMDA Antagonists" Kinney, W. A.; Lee, N. E.; et al. J. Med. Chem. 1992, 35, 4720-4726.
"N-Phenyl-2-Pyridinecarbothioamides as Gastric Mucosal Protectants" Kinney, W. A.; Lee, N. E.; et al. J. Med. Chem. 1990, 33, 327.
"Synthesis and Biological Activities of two C(23) epimers of 1a,23,25(OH)3-24-Oxo-19-nor-Vitamin D3: Novel Analogs of 1a,23(S),25(OH)3-24-Oxo-Vitamin D3, a Natural Metabolite of 1a, 25 (OH)2-Vitamin D3" N. E. Lee, G. S. Reddy, D. S. Rao, A. J. Brown, M. J. Campbell, H. P. Koeffler, S. Peleg, H. F. DeLuca and Paul G. Williard, submitted to Steroids.
"Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs and other compounds" W. A. Kinney, S. Jones, X. Zhang, M. N. Rao, M. Bulliard, H. Mechler, N. E. Lee U.S. Patent, WO 98/24800 1997
"Catalytic Asymmetric Reduction of Enamines" N.E. Lee, S. L. Buchwald U.S. Patent 5,489,682, Feb 6, 1996.
"Catalytic Asymmetric Reduction of Trisubstituted Olefins" R. O. Broene, N.E. Lee, S. L. Buchwald International Patent WO 95/02567 Jan., 1995.
"4-Azatricylco[126.96.36.199(3,8)]undecylarylpiperazines with Anxiolytic Activity"Kinney, W. A.; Lee, N. E. U.S. Patent 5,021,569, June 4, 1991.
"2-Pyridinecarbothioamides, Process for Preparation thereof and Pharma-ceutical Compositions Comprising the Same" Kinney, W. A.; Lee, N. E. U.S. Patent 4,958,023, September 18, 1990.
"2-Pyridinecarbothioamides and Pharmaceutical Compositions Comprising the Same" Kinney, W. A.; Lee, N. E. U.S. Patent 4,873,238, October 10, 1989.
RESEARCH GRANTS & AWARDS
Molecular Modeling in the Undergraduate Chemistry and Pharmacy Curricula,(Colleges of the Fenway/Davis Foundation Grant, with Len Soltzberg, Ahmed Mehanna, Lawrence Gracz) 1999-2000, $14,400.
Development of a new method for synthesis of optically active medium size lactamsfrom cyclic imidates. (Research Corp. Cottrell College Science Award) 1995-1997, $ 34,400.
Simmons Research Fund: 1994-1995, $1300.
Faculty Travel Award sponsored by American Chemical Society - May 1995.
Excellence in Teaching Award, Simmons College, 1999
Northeast Student Chemistry Research Conference, M. I. T., Cambridge, MA. April 1999. "Chiral Reduction of a Steroidal a,b-Alkynone t-Butyl side Chain", Ayako Honda, T. B. Gooding, A. P. Berger, N. E. Lee.
216th National Meeting of the American Chemical Society, Boston, MA. August, 1998. "Chiral Reduction of a Steroidal a,b-Alkynone Side Chains", T. B. Gooding, A. P. Berger, N. E. Lee.
216th National Meeting of the American Chemical Society, Boston, MA. August, 1998. "Study of Synthesis and Rearrangement of Cyclic Imidates", Kathryn Schreiber, Yilin Shao, Natalie Hill, Kiieuchinh Tran, Nancy Lee.
27th Northeast Regional Meeting of the American Chemical Society, Sarotoga Springs, NY. June 1997. "Chiral Reduction of a Steroidal a,b-Alkynone side Chain", Annise P. Berger: Nancy E. Lee.
35th Annual American Chemical Society Undergraduate Research Symposium, Boston University, Boston, MA. April 27, 1996 "Base-catalyzed cyclization of a hydroxy pentanenitrile" Kieuchinh T. Tran, Nancy E. Lee.
HONORS & SOCIETIES
National Institutes of Health Postdoctoral Fellowship, M.I.T., 1993.
Sigma Xi Scientific Research Society, M.I.T., 1994.
Advisory Board Member for Women In Science and Engineering (WISE) program, Brown University, 1991-1993.
M.I.T. Association for Postdoctoral Women, 1993.
Phi Lambda Upsilon Honorary Chemical Society, Univ. of Pennsylvania, 1985.
American Chemical Society, 1985-present.